Endocrine Abstracts

The purpose of the study: To examine the incidence of neuroendocrine complications after radiation therapy (RT) of pituitary somatotropinomas.Materials and methods: 30 patients surveyed after receiving RT at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36 to 71 years. 37% of them had pituitary macroadenoma with para-, supra-, and infrasellar growth. Duration of illness was 15 years on aver...

Aim: To evaluate the effectiveness of radiation therapy (RT) in patients with acromegaly, depending on the age of patients and the activity of pituitary adenomas.Materials and methods: The subject of the study were 50 patients (women-36, men-14) with acromegaly who received gammatherapy in a total dose of 45–60 Gr of 20–25 fractions every other day. The duration of the disease was 15 years on average. In general, the age of patients rang...

Aim: To study the relationship between the age of patients and the dynamics of the size of somatotropinomas after radiation therapy (RT).Materials and methods: The object of the study is 94 patients with acromegaly who received RT. The average age was 43.8 ± 10.4 years. The patients were divided by age into the following groups: Group I 16-29 years old (9 patients); II group 30-44 years old (44 patients); III group 45-59 years old (34 patients); IV gr...

Purpose: To assess the effect of radiation therapy (RT) in patients with acromegaly, depending on the age of the patients and the activity of the formation.Materials and methods: The object of the study was 50 patients (36 women and 14 men) with acromegaly who received gamma-therapy in a total dose of 45-60 Gr. The age of patients ranged from 29 to 77 years. By age, the patients were divided into 3 groups: 1st age group-29–44years old-23patients (46...

Aim: To study the course of clinical symptoms in women with prolactinomas.Material and research methods: The study included the results of clinical examination and treatment of 73 patients with prolactin-secreting pituitary adenomas. In the main group, 84.9% (62 women) and 15.1% (11 men) aged from 17 to 74 years old, the average age was (38.5±12.6 years). All patients were divided into 2 groups depending on the size of the education. Group I consist...

The purpose of the study: To examine the incidence of neuroendocrine complications after RT of pituitary somatotropinomas.Materials and methods: Thirty patients surveyed after receiving radiation therapy (RT) at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36–71 years. 37% of them had pituitary macroadenoma with para-, supra-, infrasellar growth. Duration of illness was on average 15 ...

Purpose of the study: To determine the gender differences in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with somatotropic pituitary adenomas after radiation therapy (RT).Materials and research methods: The object of the study is 94 patients with acromegaly receiving RT in a total dose of 45–50 gray. Of these, 26 (27.7%) are men and 68 (72.3%) are women. The peak manifestation of acromegaly in the total sample was in th...

The aim of the study was to study the incidence of osteo-articular complications in patients with acromegaly in the Ferghana Valley.Materials and methods: 129 patients with acromegaly in the Ferghana Valley who were included in the national register of acromegaly were examined. Of these, men – 46 (35.7%), women – 83 (64.3%). The average age of the patients was (48 ± 8.7 years). By age, patients were divided into three groups: 1 group &#8...

Summary: Objective: To study the clinical manifestations of musculoskeletal complications (MSC) of acromegaly, to improve the early diagnosis of the disease.Materials and methods: 150 patients with acromegaly were examined who were observed at the RSSPMC of Endocrinology during the period from 2000 to 2020. The age of patients ranged from 19 to 76 years and averaged 43 ± 8.6 years. Of these, 65 (43.3%) were men and 85 (56.7%) women. Moreover, the du...

Aim: The work was initiated to study prolactin levels in hormonally inactive pituitary adenoma by the size of the tumor.Material and methods: We examined 85 patients with hormonally inactive pituitary adenomas, 45 women and 40 men among them aged from 18 to 50 years (mean age 44.5±3.85 years). The disease duration from the onset to diagnosis based on the medical history and MRI ranged from 1 to 15 years.Results and discussion:...